150 adolescents with autism. decrease disruptive behaviors associated with ASD

A placebo-controlled clinical trial reported that the administration of whole-plant cannabis extracts were safe and effective in a cohort of 150 adolescents with autism. Researchers reported: “In this study, we have demonstrated for the first time in a placebo-controlled trial that cannabinoid treatment has the potential to decrease disruptive behaviors associated with ASD, with acceptable tolerability. … Disruptive behavior on the CGI-I [Clinical Global Impression-Improvement scale] was either much or very much improved in 49 percent [of subjects taking] whole-plant extract versus 21 percent on placebo. Median SRS [Social Responsiveness Scale] Total Score (secondary-outcome) improved by 14.9 [points] on whole-plant extract versus 3.6 points after placebo.